How Amicus Therapeutics Is Addressing the Significant Unmet Needs for Rare and Orphan Diseases

Amicus Therapeutics has been at the forefront of individualized medicine in the biotechnology industry. The company focuses on rare and orphan diseases treatment using technologies that are science driven to deliver ultimate benefits to the patients. Amicus believes that positioning themselves at the forefront of developing therapies for unmet needs it the only way to help the vast majorities of patients with rare devastating diseases. Therefore, the company has a robust development pipeline of other treatments for different genetic diseases.



As a global biotechnology company, Amicus Therapeutics has unique platform technologies in development for people with disorders such as lysosomal storage disorders (LSDs), and Pompe disease as well as skin disorders such as the epidermolysis Bullusa. Precisely, Amicus product development is based on advanced replacement therapy platform and concentrates on ERTs (Enzyme replacement therapies). In the recent years, the company has been noted to have the broadest portfolio of pharmacological chaperones in the industry (YourBeautyCraze).



Amicus Therapeutics has recently advanced its precision product Migalastat, in treating patients with Fabry disease (alpha-galactosidase A deficiency) a rare disorder where sphingolipids are not well metabolized. Previous Fabry disease therapies involved using ERT to manage the ailment, but Amicus Therapeutics therapy does not replace the enzymes, rather it helps the ones that are produced to work better ( The company estimates that more than half of Fabry disease patient could benefit from this treatment.The company has also collaborated with GlaxoSmithKline as well as JCR pharmaceutical to investigation preclinical programs in other rare diseases such as the CDKL5 deficiency.



In 2009, Amicus faced a major financial setback after a termination of an agreement with The Shire, which led to a major corporate reconstruction. However, the company has consistently innovated new ERT products for Pompe diseases, LSD and Fabry diseases. Amicus therapeutics center of inventive science is the need of patients with rare diseases, so the company continues to develop new products that will make the difference in the lives of these patients as well as their caregiver.


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Significance of Personal Cyber Security and Rubica firm

It is important to note that cyber attacks are causing extensive damage to the individuals, companies, and governments. Therefore, institutions should respond through the adoption of personal cybersecurity measures that are strict.

The question on “why cybersecurity is important?” gets a breakdown of INN into three essential answers. INN stands for the Investing News Network. Together with the expansion of cyber attacks, the amounts spent on money firms concerning Personal cybersecurity, and the intensifying severity of such assaults gives an illustration of what makes the market important.

Rubica refers to a firm enhancing privacy and digital personal cyber security. The company has a secure and private network together with a group of experienced personnel concerning elite cyber. It is through this that they are capable of offering digital security at the level of the leading firms globally. Even though Rubica is quite refined, it’s simple to use.

The platform offers the most straightforward and very efficient way of locking down one’s online security. To improve the safety, it could entail spending weeks reconfiguring wi-fi, changing passwords then updating software.

Rubica enhances the elimination of the complexities associated with personal cyber security as well as privacy. They do it by improving its care at the background. Their cyber ops group enhances safety from criminals’ trials alongside the collection of people’s data to utilize it for financial benefit.

It is remarkable that by installing the Rubica application to every computer, smartphone and tablet are all that need be done then Rubica firm will accomplish the rest of the tasks.

Osteo Relief Institute New Jersey Nonsurgical Treatment

Osteo Relief Institutes founded in the year 2012. The nonsurgical relief for arthritis institute is the United States privately owned company. The Institute primary aim is to help patients avoid costly surgery treatments by offering secure and impressive joint pains medications that provide little to no procrastination such as the joint injection. The organization team comprises of highly trained staff in fields of patient care and communication. Osteo relief institute headquarters its medical practices in Wall, New Jersey.


Osteo Relief Institute is made up of a group of board-certified physicians and physical therapists that believe patients should be offered treatments to satisfaction (PositiveTheFacts). The institute is uniquely combined with FDA approved and cleared technologies equipment. The institute focuses on using the most advanced up-to-date technology to give its patients the edge in getting them lasting pain relief. Osteo relief is also made up of several centers in different locations independently owned.


Osteo Relief Institute, New Jersey provides Monmouth county and nearby areas with the non-surgical relief for their knee arthritis and spinal disc pain ( Osteoarthritis is an unbearable situation that occurs in a lot of people as their bodies’ age. Osteoarthritis is the most chronic classification of arthritis and affects approximately 30 million individuals globally. The condition is severe, but with the correct treatment plan, a lot of patients can get help strengthening movements and minimal pain.

Fortunately, Osteo Relief Institute Nonsurgical treatment practice is believed be the most advanced and most efficient in the area. Osteo institute has invested in the most recent technology and types of equipment to provide accurate treatment to its patients. The nonsurgical medical institute offers risk-free first screening services to new patients.


The knee program helps patient to stay active all through and provides comfort with no or less pain. The New Jersey-based institute team delivers services to their patients in mind that every patient is unique and solves this by offering a wide selection procedure that is believed to satisfy all its different patients. The Osteo family is very affordable because it takes advantage of the advancing technology compared to surgery treatments which are costly.

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Eli Gershkovitch is a Leading Craft Beer Entrepreneur in Canada

Craft Beer in Canada


Two decades ago, most people used to recognize craft beer manufacturers as micro-breweries. These firms were traditional, non-mechanized and existed in small-scale. The situation has changed because the craft beer industry is one of the most growing economies in Canada. The consumption of the traditional beer has increased due to the recent awareness and love of the Canadian craft beer.


With dedicated manufacturers, such as Eli Gershkovitch, the craft beer industry has risen to be a top contributor to the country`s gross profit ( A report prepared by BMO Nesbitt Indicated that most Canadian craft beer companies are making double-digit revenue. Since 1995, the industry has been growing regardless of the fluctuating market.


In 2015, the craft beer breweries, in Canada, sold over 2.3 billion liters of beer. McAuslan Brewery records an annual profit of more than $20 million. Ontario Craft Breweries sells over 400,000 hectoliters of beer each year.


Craft beer breweries manufacture a variety of products. Such beer is produced in multiple tastes, brands, and flavors. The most common types of beer include Glutenberg, Red Racer, Nutcracker Porter weissbier, Stout, La Fin and Farmhouse Saison. The flavors are retailed across Europe and some parts of the U.S. Canadian craft beer breweries work day and night to satisfy the large market.

About Eli Gershkovitch


Eli Gershkovitch is one of the most successful pioneers of the Canadian craft beer. He is the founder and CEO of Steamworks, an organization of multiple craft beer companies. He started a micro-brewery, Steamworks, in 1995. The firm was a small brewpub that applied steam-power to manufacture craft beer.


Although many people did not like the traditional beer, Eli Gershkovitch enabled the product to gain a good reputation in the country. Eli Gershkovitch expanded the company by increasing its market across the U.S. and Europe. Eli Gershkovitch visited several countries in Europe to study people`s preferences.


Eli Gershkovitch`s extensive marketing skills and his connection with customers enabled him to design various flavors, tastes, and brands. His most popular brands include IPA, Gate Lager and Pale Ale. Eli has worked in the craft beer industry for more than 20 years. He utilizes his experience to manufacture the best product.

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Dr. Mark Holterman’s Journey To Revolutionize Medicine

Physician, a medical professor and attending pediatric surgeon Dr. Mark Holterman is unswerving in his approach to advancing medicine on a worldwide level.


Leveraging more than 25 years experience, Dr. Mark Holterman’s schedule takes in work as a Professor of Surgery and Pediatrics at the College of Medicine at the University of Illinois at Peoria. He also functions as an attending Pediatric General Surgeon at the Children’s Hospital of Illinois.


In addition, Dr. Mark Holterman manages Mariam Global Health, a firm that develops and executes scientific advances (


After graduating cum laude with a biology degree from Yale University, Holterman continued his education attaining a Masters Degree and Ph.D. at the University of Virginia.


He is a member of the American Diabetes Association (ADA) which carries out research and advocacy measures concerning diabetes treatment and cure. Diabetes has an impact on almost 30 million people in the United States.


The ADA recently revealed a joint initiative with Children’s Hospital Los Angeles which tackles the growing rate of type 2 diabetes that takes place in children and teenagers (MarkJHolterman.Strikingly). The two groups will offer programs that include day camps, church settings, and after-school programs.


For example, Camp PowerUp aims to get the children more involved in physical activities and instructs them on healthier food choices as a way to reduce their chances of developing diabetes.


Dr. Mark Holterman was also involved from the beginning with the Hannah Sunshine Foundation, which focuses on the use of cellular and regenerative therapies for children with rare illnesses.


A 23-year old woman named Sarah Hughes, badly affected with systemic juvenile idiopathic arthritis (SJIA), was one of three young people who motivated the foundation.


The disease, which is a subtype of juvenile idiopathic arthritis (JIA) involves organs such as the heart and lungs as well as the joints. SJIA is an autoimmune disease with no cure and affects 10 to 20 percent of children who have some type of JIA. Dr. Mark Holterman and his associates trust that early, forceful medical care for the patient be supported.


Dr. Mark Holterman has received the Innovative Research Award from the American Diabetes Association and has also written articles for Surgical Clinics of North America and the Journal of Pediatric Surgery.


Revolutionary Of Business With Glen Wakeman

Glen Wakeman is effortlessly a standout amongst the most compelling business visionaries on the planet today. He has aced his specialty and reached a level whereby only a few professionals in the sector have done so. Glen parlayed his accomplishment and turned it to mentor people who aspire to have financial security and business well-being. To date, he has assisted in transforming various organizations into profitable establishments.

In the year 2015, Glen Wakeman helped to establish SAAS organization LaunchPad Holdings LLC where he also fills in as the chief executive officer. His leadership over the years has been productive due to his ability to apply new methods to the effective running of businesses persistently. The foundation of applied methodologies entails five key components: leadership power, human capital, governance, execution in business and risk management.

What isolates Glen Wakeman from numerous different business people and investors is his groundbreaking strategy. The business mentor is always planning about another bigger and better thing to help businesses grow. The element prompted him to become a business revolutionary that gives inspiration to other people. The sharp market strategist offers significance financial advice including the most accomplished company officials. To the majority of business people, Glen Wakeman insight is always precious.

Wake man is likewise an eager blogger ( and does the best to train the maximum number of people he can. The posts in his blog entail subjects such as strategy, administration, management, emerging markets and fiscal matters. He is a man with experience having lived in six distinct nations throughout the years. His voyaging has helped him make associations with a wide range of business professionals which has earned him reputation universally.

Glen Wakeman understood that school was the initial move towards seeking after a profession in finance. Thus, in the 1970’s, he joined the University of Scranton and graduated with BS in Economics & Finance. Later, he graduated from the University of Chicago with an MBA in Finance (LinkedIn). Glen began exercising his career skills at GE Capital holding where he held different business development positions. Today, he is proud to have helped various new business people achieve their dreams.


How to Show Love to Your Loved Ones with the Securus Technologies

Securus Technologies is Technology Company operating in Dallas, Texas. The firm has been in operation since its inception in the year 1986. Since then, the business has grown, and its offices are located in various states in the United States. Securus Technologies provides employment opportunities to over 100 people and has provided services in over 2600 jails and prisons in the United States. Various financial and statistical data available, show that the company has put over $600 million in investments in the last three years.

Securus Technologies deals with a variety of services and products. Last year, the firm developed a system that will help in the control and eventual elimination of contraband phones in the market. The technology was designed in a manner that would not allow the fake phones access any mobile network. Due to the quality of its work, Securus Technologies has received over five approvals from various correctional facilities department in the United States.

The company has been on the limelight courtesy of the role it plays in the provision of telephone services across various County and State prisons. The technology has helped multiple clients plan on their visitation hours to different prisons or jails. The company uses a new system known as Anywhere Visit, to help you schedule the visitation hours. With the system, you are free to make visitations at any time without the usual time restriction standard in all correctional facilities.

For the program to work, you will need a steady internet connection, a web camera, a phone and a laptop. With these necessities, you can comfortably communicate with the inmates with a lot of ease. All you need to do is to set up an Online Securus Account. However, it is important to state that the effectiveness of the communication channel with varies from one facility to the other. Despite all the various shortcomings, the important thing is to make sure you are having fun with your loved ones.

Tobias Jaeger: The Businessman And Leader At Axiom

Tobias Jaeger is a businessman and entrepreneur who has become hugely successful owing to the numerous companies that he has founded. His first entrepreneurial venture was while he was still a student studying to get his degree. He had a keen interest in business strategies and plans of action, which is why his first company was catered to giving other companies the solutions and strategies that they could implement. The consultancy service proved to be extremely successful, which paved the way for future endeavors that Jaeger embarked on.


Soon after his first venture, his next one was in the field of gaming. He decided to tap into the e-gaming industry to found his very own poker site. He did this with the help of his business partner, who was also a professional poker player, who was well-known in the field. The site served as a teaching tool to all those who wanted to take up the game for a professional play or to make a little more money on the side. Once again, this company too turned out to be incredibly lucky and had a large number of people logging on every day to improve their skills at the game.


Jaeger gained popularity when he had an opportunity to work in the entertainment sector. This also fueled the foundation for the company that Jaeger currently runs today. He was part of an international documentary which focused on the business models that companies currently need to employ to set themselves apart in the food industry. Soon after working at this, he decided to start up his own company for the entertainment industry. The company was known as Axiom Venture Capital and was one which offered media companies the financial backing that they need to establish themselves in the industry. Currently, Jaeger leads the company from his position as Managing Partner. Using his incredible business knowledge, he has brought on numerous clients to the company, providing them with the tools that they need to set up their business.


In addition to his work, Jaeger has also been a part of numerous philanthropic endeavors. He is the founder of an NGO that works to create awareness and support for the people that are working in the German Armed Forces. The organization also helped to raise funds for these troops, so that they can have all the necessities they need in exchange for their selfless service for the country.


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Avaaz Campaigns Save The Lives Of Dogs In China And India

When Avaaz becomes aware of a critical issue in the world they take steps to make it right. There is a festival that takes place in Yulin, China every year. During this time thousands of dogs are brutally killed, boiled, and served for China’s dog meat festival. The global community of Avaaz had reached their limits and decided enough was enough. Three million members of Avaaz partnered with groups for animal rights both in and out of China and created the worlds largest online call in history. Avaaz used their voice to reach Beijing as well as embassies around the globe. Avaaz then conducted an opinion poll and discovered the citizens of China were greatly opposed to this annual festival. The voices of Avaaz were heard by the officials in Yulin and they vowed to permanently close the festival. The appropriate government agencies and Yulin authorities have taken actions to ensure this festival never happens again.

Avaaz once again fought for the animals when they discovered the Indian Army had been killing unfit and old dogs and horses. These animals had provided loyal service to the army in extremely dangerous combat. Thousands of members of Avaaz teamed with India’s Animal Welfare Board to pressure the Defense Ministry. Avaaz felt these loyal animals deserved to be rehabilitated. Many members of Avaaz wrote to the Defense Ministry directly and even offered homes for the dogs retired from the Army. Just a few weeks after Avaaz launched their campaign the Indian Army contacted the Animal Welfare Board. They requested the development of a rehabilitation plan for the animals. The Defense Ministry agreed to the funding and made an official announcement that they were ending the brutality of humane euthanasia. Shortly afterwards Avaaz received a letter from the Animal Welfare Board of India thanking them for the trouble they went through to write the government letters. The letter was signed truly, truly grateful.

Motivational Speaker and Manager-Vincent Parascandola

Growing up as a young man; Vincent Parascandola knew he wanted to be in the management field. After his High School graduation, Mr. Vincent joined Pace, University, New York where he studied and graduated with a Bachelor of Science Degree. After his University graduation; Vincent Parascandola began his career serving at Prudential back in 1987 working as an agent. Mr. Vincent was among the hard working staffs in the organization and was devoted to the duties and responsibility of the firm. While still working at the company; Vincent was lucky to be named the National Rookie of the year. He worked at Prudential for three years and later moved to MONY Life Insurance Company in 1990.

Vincent Parascandola is a leader and while working at MONY Life Insurance Company he was head of several top positions both locally as well as international. According to Rocket Reach, in 2004 Vincent Parascandola joined AXA Advisors. He was first given the role of a President of one of the units of AXA Equitable; Advantage Group. AXA Equitable was purposely created to attract seasoned economic professionals. Mr. Vincent has also held other top positions in the group including being the co-manager of one of the organization’s branches located in New York.

Vincent has been a leader who throughout his career has shown positive leadership skills which have enabled him to hold various leadership and management positions in the insurance industry. Currently, Mr. Vincent Parascandola is the Senior Executive Vice President of AXA Advisor. In the Insurance Company; Vincent is responsible for hiring staff, retentive, management, sales, growth of both new as well as experienced financial professionals, as well as the productivity of the organization. In 2014, Mr. Vincent was invited to go back to his former university to give a commencement to the graduation c lass of 2014. Being a prominent leader; Parascandola has been honored on several occasion including Master Agency Awards and GAMA’s Career Development. Vincent is not only a leader but he is also a motivational speaker who has been invited to events to give his speech including GAMA;s national lamb meeting and LIMRA distribution conference. Vincent is also a former Chair of LIMRA’S field Officers Committee.